![]() However, it can be said that herbal medicine has been associated with life since the beginning of human existence. Regardless of accessibility, availability, and affordability, both have saved millions of lives. However, it is quite difficult to say who the winner is nobody can ignore the crucial role of traditional medicine and modern medicine in overcoming the disease’s attack. ![]() Some other diseases, such as different types of cancers including melanoma, later emerged, and are mostly related to human genetics backgrounds and one’s lifestyle. The history of humans and pathogens combat back to many years ago. Well-structured, randomized clinical studies on cannabinoid use in melanoma patients would also be required prior to cannabinoids becoming a viable and recognized therapeutic option for melanoma treatment in patients. Further preclinical and animal studies are required to determine the underlying mechanisms of cannabinoids-mediated inhibition of cancer-signaling pathways. The findings revealed cannabinoids, individually or combined, reduced tumor growth and promoted apoptosis and autophagy in melanoma cells. From a total of 622 potential studies, six in vivo studies assessing the use of cannabinoids for treatment of melanoma were deemed eligible for the final analysis. Systematic searches were carried out in PubMed, Embase, Scopus, and ProQuest Central databases for relevant articles published from inception. Therefore, the aim of this study was in the first instance to review the evidence from in vivo studies on the effects of cannabinoids on melanoma. Despite prohibited use of Cannabis in most parts of the world, in recent years there have been renewed interests in exploiting the beneficial health effects of the Cannabis plant-derived compounds. plant, can reduce cell proliferation and induce apoptosis in melanoma cells. Several studies have shown that “cannabinoids”, the major compounds of the Cannabis sativa L. While there has been substantial progress in the treatment of cancer in general, malignant melanoma, in particular, is resistant to existing medical therapies requiring an urgent need to develop effective treatments with lesser side effects. Chemical stocks gained due to the 'China plus 1' strategy adopted by many countries, while commodity price increases lowered demand for consumer goods, which hurt those stocks.Melanoma is the fourth most common type of cancer diagnosed in Australians after breast, prostate, and colorectal cancers. While sectors like IT gained the most due to demand for new technologies post Covid-19, shortages of semiconductors led to poor performance from auto stocks. In addition to this, central banks are acting fast, there are geopolitical tensions and the impact of Covid 19 - factors that have combined to lead to sharp volatility in the markets.įortunes of several industries change quickly, thereby leading to divergence of returns. "If the fund performance deteriorates due to a change in fund management, or change in style, it may make sense to pause the SIP in the scheme and hold the accumulated money there for some time to negate the impact of exit load and tax," said Anup Bhaiya, CEO of Money Honey Financial Services.įinancial planners also believe the sharp difference in scheme performance is happening due to a fast-changing global environment. He believes investors should give two years to a fund manager and if there is underperformance still, other options can be looked at. Roongta believes while there is no single way to avoid an underperforming fund, many times strategies adopted by a fund manager could take time to play out. If they are doing well and one particular scheme has underperformed, one should wait as a couple of stock calls would not have worked," said Harshvardhan Roongta, CFP, Roongta Securities. "Look at the track record of other schemes managed by the fund house. It is possible that a bottom performer could have taken bets that have not worked, but could work going ahead. Many investors are tempted to go by past performance and exit the bottom performers, but financial planners said this may not always work. Motilal Oswal Flexicap the yield is 5.95%.įinancial planners believe funds should beat their benchmarks and weed out those not performing even after 2-3 years.
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